Protamine induces endothelium-dependent vasodilatation of the pulmonary artery.


BACKGROUND Protamine sulfate, which is used for heparin neutralization, has been reported to induce catastrophic pulmonary vasoconstriction after infusion. However, in the systemic circulation, protamine infusion induces hypotension due to peripheral vasodilation. METHODS To determine whether protamine also could induce vasodilation in the pulmonary… (More)


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