Protamine-induced permeability changes in the neutrophil plasma membrane as the basis of activation of exocytosis.

@article{Elferink1992ProtamineinducedPC,
  title={Protamine-induced permeability changes in the neutrophil plasma membrane as the basis of activation of exocytosis.},
  author={Jan G. R. Elferink},
  journal={Cell biochemistry and function},
  year={1992},
  volume={10 1},
  pages={35-40}
}
Protamine induces a gradual change in plasma membrane permeability in rabbit neutrophils, which is evident from the increase of indol fluorescence, and the leakage of quin2 from quin2-loaded neutrophils. The influx of extracellular Ca2+ into the neutrophil provides an explanation for exocytosis which occurs in the presence of Ca2+ and protamine. The dependence of exocytosis on Ca2+ concentration follows the same pattern as is observed in neutrophils permeabilized by other means. In the absence… CONTINUE READING