Protamine enhances fibrinolysis by decreasing clot strength: role of tissue factor-initiated thrombin generation.

@article{Nielsen2006ProtamineEF,
  title={Protamine enhances fibrinolysis by decreasing clot strength: role of tissue factor-initiated thrombin generation.},
  author={Vance G. Nielsen},
  journal={The Annals of thoracic surgery},
  year={2006},
  volume={81 5},
  pages={
          1720-7
        }
}
BACKGROUND Excessive protamine administration to neutralize heparin after cardiopulmonary bypass has been implicated as a cause of postoperative hemorrhage. Protamine directly inhibits thrombin and tissue factor (TF)-mediated activation of factor VII. However, the half-life of protamine is only 4.5 minutes; thus the purpose of this study was to determine if protamine could enhance fibrinolysis, explaining the delayed, protamine-associated hemorrhage observed in the postoperative period… CONTINUE READING
BETA
Highly Cited
This paper has 22 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Similar Papers

Loading similar papers…