Protamine as an efficient membrane-translocating peptide.

@article{Reynolds2005ProtamineAA,
  title={Protamine as an efficient membrane-translocating peptide.},
  author={F. E. Reynolds and Ralph Weissleder and Lee Josephson},
  journal={Bioconjugate chemistry},
  year={2005},
  volume={16 5},
  pages={1240-5}
}
Protamine, a mixture of positively charged proteins from salmon roe used in diverse pharmaceutical applications, was reacted with the N-hydroxysuccinimide ester of tetramethylrhodamine to yield tetramethylrhodamine-labeled protamines (Pro(Rh)) containing one mole of fluorochrome per mole of protein. The internalization of tetramethylrhodamine-labeled protamine (Pro(Rh)) and the fluorescein-labeled tat peptide (Tat(Fl)) showed a similar dependence on time and concentration. Pro(Rh) and Tat(Fl… CONTINUE READING

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