Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.

@article{Aminova2005ProsurvivalAP,
  title={Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.},
  author={Leila R. Aminova and Juan Carlos Chavez and Junghee Lee and Hoon Ryu and Andrew L Kung and Joseph C. LaManna and Rajiv R Ratan},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 5},
  pages={3996-4003}
}
Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator involved in adaptation to hypoxic stress. Previous studies from our laboratory demonstrated that pharmacological activators of HIF-1 (e.g. deferoxamine, cobalt chloride) could also protect cultured primary neurons or an immortalized hippocampal neuroblast line (HT22) from oxidative stress-induced death. However, whether HIF-1 activation is sufficient to abrogate neuronal death resulting from oxidative stress or other hypoxia… CONTINUE READING
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