Prostratin antagonizes HIV latency by activating NF-kappaB.

  title={Prostratin antagonizes HIV latency by activating NF-kappaB.},
  author={Samuel A F Williams and Lin-Feng Chen and Hakju Kwon and David Fenard and Dwayne A Bisgrove and Eric Verdin and Warner C. Greene},
  journal={The Journal of biological chemistry},
  volume={279 40},
A subset of quiescent memory CD4 T cells harboring integrated but transcriptionally silent proviruses poses a currently insurmountable barrier to the eradication of the human immunodeficiency virus (HIV) in infected patients. Induction of HIV gene expression in these latently infected cells by immune activating agents has been proposed as one approach to confer sensitivity to antiretroviral therapy. Interest has recently focused on the non-tumor-promoting phorbol ester, prostratin, as a… CONTINUE READING
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