Prosthetic metals interfere with the functions of human osteoblast cells in vitro.

@article{Wang1997ProstheticMI,
  title={Prosthetic metals interfere with the functions of human osteoblast cells in vitro.},
  author={Jianguo Wang and Barbara Wicklund and Ramon B Gustilo and Dean T. Tsukayama},
  journal={Clinical orthopaedics and related research},
  year={1997},
  volume={339},
  pages={
          216-26
        }
}
The release of metals from total joint prostheses may contribute to periprosthetic bone loss manifested as osteolysis. The effects of titanium, cobalt, and chromium on human osteogenic sarcoma cells (osteoblastlike cells) were investigated in vitro. Titanium, cobalt, and chromium at concentrations of 1, 10, and 100 ng/ml did not cause any changes in the cell growth, viability, and injury after 72-hour incubation with the cells. Titanium, cobalt, and chromium at concentrations ranging from 0.01… CONTINUE READING
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