Prostatic intraepithelial neoplasia and intestinal metaplasia in prostates of probasin-RAS transgenic mice.

@article{Scherl2004ProstaticIN,
  title={Prostatic intraepithelial neoplasia and intestinal metaplasia in prostates of probasin-RAS transgenic mice.},
  author={Alexis Scherl and Jiu-feng Li and Robert Cardiff and Nicole Schreiber-Agus},
  journal={The Prostate},
  year={2004},
  volume={59 4},
  pages={448-59}
}
BACKGROUND Activation of the RAS pathway has been implicated in the pathogenesis of many types of human cancers, including prostate cancer. Here we employed a transgenic approach to assess the potential contribution of RAS to prostate carcinogenesis. METHODS Probasin-RAS (Pb-RAS) transgenic mice were generated and shown to express high levels of activated RAS in the prostate lobes. Transgenic prostates were compared to normal controls by histology and immunohistochemistry with relevant… CONTINUE READING

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