Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene.

@article{Li2006ProstaticIN,
  title={Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene.},
  author={Zhe Li and Matthias Szabolcs and Joseph D. Terwilliger and A. Efstratiadis},
  journal={Carcinogenesis},
  year={2006},
  volume={27 5},
  pages={1054-67}
}
NEU (ERBB2) and other members of the epidermal growth factor receptor (EGFR) family have been implicated in human prostate cancer (CAP) development and progression to an androgen-independent state, but the extent of involvement and precise role of this signaling pathway remain unclear. To begin addressing such open questions in an animal model, we have developed a transgenic line in which an oncogenic Neu cDNA (Neu*) driven by the probasin gene promoter is overexpressed in the mouse prostate… CONTINUE READING
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Patho - logical and molecular aspects of prostate cancer

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