Prostate tumour overexpressed-1 promotes tumourigenicity in human breast cancer via activation of Wnt/β-catenin signalling.

@article{Cui2016ProstateTO,
  title={Prostate tumour overexpressed-1 promotes tumourigenicity in human breast cancer via activation of Wnt/β-catenin signalling.},
  author={Yanmei Cui and Weifeng Ma and Fangyong Lei and Qing Li and Yanhong Su and Xi Lin and Chuyong Lin and Xin Zhang and Liping Ye and Shu Lian Wu and Jun Li and Zhongyu Yuan and Libing Song},
  journal={The Journal of pathology},
  year={2016},
  volume={239 3},
  pages={297-308}
}
Breast cancer is the most common malignancy in females. The presence of cancer stem cells (CSCs) is the main cause of local and distant tumour recurrence and is associated with poor outcome in breast cancer. However, the molecular mechanisms underlying the maintenance of CSCs remain largely unknown. This study demonstrates that prostate tumour overexpressed-1 (PTOV1) enhances the CSC population and augments the tumourigenicity of breast cancer cells both in vitro and in vivo. Moreover, PTOV1… CONTINUE READING
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