Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1.

@article{KoganSakin2009ProstateSC,
  title={Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1.},
  author={Ira Kogan-Sakin and Merav Cohen and Nicole Paland and Shalom Madar and Hilla Solomon and Alina Molchadsky and Ran Brosh and Yosef Buganim and Naomi Goldfinger and Helmut Klocker and Jack A Schalken and Varda Rotter},
  journal={Carcinogenesis},
  year={2009},
  volume={30 4},
  pages={698-705}
}
It is well accepted that tumor microenvironment is essential for tumor cells survival, cancer progression and metastasis. However, the mechanisms by which tumor cells interact with their surrounding at early stages of cancer development are largely unidentified. The aim of this study was to identify specific molecules involved in stromal-epithelial interactions that might contribute to early stages of prostate tumor formation. Here, we show that conditioned medium (CM) from immortalized non… CONTINUE READING

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