Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth.

Abstract

Prostate stem cell antigen (PSCA) is a cell surface antigen expressed in normal human prostate and over expressed in prostate cancer. Elevated levels of PSCA protein in prostate cancer correlate with increased tumor stage/grade, with androgen independence and have higher expression in bone metastases. In this study, the PSCA gene was isolated from the… (More)
DOI: 10.1038/mt.2009.66

Topics

Cite this paper

@article{Ahmad2009ProstateSC, title={Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth.}, author={Sarfraz Ahmad and Garrett Casey and Paul Sweeney and Mark Tangney and Gerald C O'sullivan}, journal={Molecular therapy : the journal of the American Society of Gene Therapy}, year={2009}, volume={17 6}, pages={1101-8} }