Prostate specific membrane antigen (PSMA): A novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells

  title={Prostate specific membrane antigen (PSMA): A novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells},
  author={Yiming Zhang and Zheng-hui Guo and Tao Du and Jieqing Chen and Wei Wang and Kewei Xu and Tianxin Lin and Hai Huang},
  journal={The Prostate},
Regulated activation of p38 is crucial for cell proliferation, survival, and metabolism. Our previous studies had showed that prostate specific membrane antigen (PSMA) can facilitate the proliferation, migration, survival of the LNCaP prostate cancer cell line, but the mechanisms are poorly defined. 

Prostate specific membrane antigen knockdown impairs the tumorigenicity of LNCaP prostate cancer cells by inhibiting the phosphatidylinositol 3‐kinase/Akt signaling pathway

The results reveal that PI3K/Akt signaling pathway inhibition may serve as a novel molecular mechanism in LNCaP prostate cancer cells of PSMA knockdown and suggest that Akt (Ser473) may play a critical role as a downstream signaling target effector of PSma in this cellular model.

The interplay between MDM2 and PSMA in metastatic breast cancer cells

Results indicate that MDM2, AKT and PSMA may represent a new pathway which could be targeted for therapy for breast tumours and perhaps other types of cancer.

Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer.

The results suggest that the combination of a PI3K inhibitor and a PSMA-targeted protein synthesis inhibitor toxin represents a promising novel strategy for advanced prostate cancer therapy that should be further investigated.

New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen

The objective of this contribution is to review the current role of PSMA as a marker for PCa diagnosis, imaging, and therapy and to focus in particular on its intracellular activities and functions.

The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease

The biological roles that PSMA/GCPII plays, both in normal and diseased tissues, and the current therapies exploiting its activity that are at the preclinical stage are discussed, as well as hurdles that need to be overcome to make them effective and viable.

TES inhibits colorectal cancer progression through activation of p38

Examination of TES protein levels in CRC tissue samples and cell lines indicates that TES functions as a necessary suppressor of CRC progression by activating p38-MAPK signaling pathways.

Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells.

The potential ability of sesamin to downregulate the secretion of cytokines and the expression of cell proliferative- and invasive-related gene products induced by LPS was shown to be via the p38 mitogen-activated protein kinase (p38-MAPK) and NF-κB signaling pathways, which may be one of the mechanisms of the anticancer activity of this sesamination agent in prostate cancer cells.

p38 MAPK Inhibition Mitigates Hypoxia-Induced AR Signaling in Castration-Resistant Prostate Cancer

It is shown that targeting the p38 MAPK protein kinase can inhibit growth and survival of both well-oxygenated and hypoxic castration resistant prostate cancer cells and prolong survival of tumor bearing mice, and that hypoxia does not offer protection against targeting this pathway.

Prostate-specific membrane antigen (PSMA) targeted singlet oxygen delivery via endoperoxide tethered ligands.

It is demonstrated that cytotoxic singlet oxygen can be delivered regioselectively into prostate specific membrane antigen (PSMA) overexpressing lymph node carcinoma (LNCaP) cells, and this targeted singlets oxygen delivery can serve as an effective therapeutic tool.

The Role of Testin in Human Cancers

Understanding the molecular functions of testin may be crucial in development personalized treatment, what suggest its potential usage in immunotherapy and more.



Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer

In this review, the regulation of PSMA expression within the cells, and significance of its expression in prostate cancer and metastasis are discussed.

The p38 transduction pathway in prostatic neoplasia

It is concluded that overexpression of α‐PAK, MEK‐6, p38, p‐Elk‐1, and p‐ATF‐2 in BPH, and more intensely in PC, enhances cell proliferation.

Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells.

  • J. PintoB. Suffoletto W. Heston
  • Biology
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1996
It is demonstrated clearly that LNCaP cells, which highly express PSM, hydrolyze gamma-glutamyl linkages of MTXGlu3 and pteroylpentaglutamate as substrates and that cancer cells that express this enzyme are resistant to methotrexate therapy.

Lentivirus-mediated RNAi knockdown of prostate-specific membrane antigen suppresses growth, reduces migration ability and the invasiveness of prostate cancer cells

It is demonstrated that lentivirus-mediated RNA interference silencing targeting prostate-specific membrane antigen might reduce the proliferation, and induce potent antitumor activity of LNCaP and DU-145 cells.

p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells.

The p38 kinase is revealed as a key signaling molecule differentially regulated by H-ras and N-ras, leading to H-ra-specific cell invasive and migrative phenotypes in human breast epithelial cells.

A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells

It is reported that p38α is required for colorectal cancer cell homeostasis as the inhibition of its kinase function by pharmacological blockade or genetic inactivation causes cell cycle arrest, autophagy and cell death in a cell type-specific manner.

Prostate-specific membrane antigen expression in normal and malignant human tissues.

The decrease in PSMA immunoreactivity noted in advanced prostate cancer suggests that expression of this molecule may be linked to the degree of tumor differentiation and the neoexpression of PSMA in endothelial cells of capillary beds in certain tumors may be related to tumor angiogenesis and suggests a potential mechanism for specific targeting of tumor neovasculature.

Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.

Activation of p38 Has Opposing Effects on the Proliferation and Migration of Endothelial Cells*

The results suggest that cellular decisions regarding migration and proliferation are influenced by p38 activity and that prolonged activation of p38 may result in an anti-angiogenic phenotype that contributes to endothelial dysfunction.