Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro.

@article{Yao2006ProstateSM,
  title={Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro.},
  author={Veronica Yao and Dean John Bacich},
  journal={The Prostate},
  year={2006},
  volume={66 8},
  pages={
          867-75
        }
}
BACKGROUND Prostate specific membrane antigen (PSMA) expression is correlated with stage and grade of prostate cancer suggesting that it confers a growth advantage. We studied if PSMA folate hydrolase activity provides cells a growth advantage in a low folate (LF) micro-environment by hydrolyzing extracellular poly-gamma-glutamated folate to a form that cells can import. METHODS Proliferation of LNCaP and DU-145 cells was assessed in media containing low (LF), physiological (PF), or high (HF… CONTINUE READING

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