Prostate-specific membrane antigen (PSMA) enzyme activity is elevated in prostate cancer cells.

@article{Lapidus2000ProstatespecificMA,
  title={Prostate-specific membrane antigen (PSMA) enzyme activity is elevated in prostate cancer cells.},
  author={Rena G. Lapidus and Carol W. Tiffany and John T Isaacs and Barbara S Slusher},
  journal={The Prostate},
  year={2000},
  volume={45 4},
  pages={
          350-4
        }
}
BACKGROUND Prostate-specific membrane antigen (PSMA) is a glutamate carboxypeptidase that cleaves terminal carboxy glutamates from both the neuronal dipeptide N-acetylaspartylglutamate (NAAG) and gamma-linked folate polyglutamate. The prostate enzyme has activity in both the membrane and cytosolic fractions termed PSMA and PSMA', respectively. METHODS Using a NAAG hydrolytic radioenzymatic assay, we quantitated the enzymatic activity of PSMA and PSMA' in normal, benign prostatic hyperplasia… CONTINUE READING