Prostate-specific antigen levels in relation to consumption of nonsteroidal anti-inflammatory drugs and acetaminophen: results from the 2001-2002 National Health and Nutrition Examination Survey.

@article{Singer2008ProstatespecificAL,
  title={Prostate-specific antigen levels in relation to consumption of nonsteroidal anti-inflammatory drugs and acetaminophen: results from the 2001-2002 National Health and Nutrition Examination Survey.},
  author={Eric A. Singer and Ganesh S. Palapattu and Edwin van Wijngaarden},
  journal={Cancer},
  year={2008},
  volume={113 8},
  pages={2053-7}
}
BACKGROUND Inflammation has been implicated in prostate carcinogenesis; therefore, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) has the potential of decreasing the risk of prostate cancer. However, to the authors' knowledge the precise correlation between oral NSAID use, serum prostate-specific antigen (PSA), and prostate cancer risk is unknown. To further characterize this association, the authors evaluated serum PSA levels with regard to NSAID and acetaminophen consumption in a… CONTINUE READING

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Linear regressions were performed on log - transformed PSA levels , accounting for the complex survey design , to evaluate the relations between PSA and the use of NSAIDs and acetaminophen after adjusting for the effects of age , race , educational level , smoking status , body mass index , coexisting inflammatory conditions , and heart disease .
PSA levels among NSAID users were 0.9 times the levels among nondrug takers ( P = .038 ) , whereas PSA levels among acetaminophen users were 0.76 times the levels in nondrug takers ( P = .14 ) .
acetaminophen consumption displayed a negative association with PSA levels , namely , individuals who reported using NSAIDs ( 19.8% ) or acetaminophen ( 1.3% ) regularly had lower PSA levels than individuals who did not take these drugs , although the impact of acetaminophen was not statistically significant .
acetaminophen consumption displayed a negative association with PSA levels , namely , individuals who reported using NSAIDs ( 19.8% ) or acetaminophen ( 1.3% ) regularly had lower PSA levels than individuals who did not take these drugs , although the impact of acetaminophen was not statistically significant .
To further characterize this association , the authors evaluated serum PSA levels with regard to NSAID and acetaminophen consumption in a large cross - sectional study of men in the US . METHODS .
acetaminophen consumption displayed a negative association with PSA levels , namely , individuals who reported using NSAIDs ( 19.8% ) or acetaminophen ( 1.3% ) regularly had lower PSA levels than individuals who did not take these drugs , although the impact of acetaminophen was not statistically significant .
Prostate - specific antigen levels in relation to consumption of nonsteroidal anti - inflammatory drugs and acetaminophen : results from the 2001 - 2002 National Health and Nutrition Examination Survey .
Individuals who stated they took both NSAIDs and acetaminophen ( 0.99% ) on a regular basis had higher PSA levels ( 1.8 times greater ) , although not statistically significantly so ( P = .24 ) , than individuals who stated they did not take either of these drugs regularly .
Inflammation has been implicated in prostate carcinogenesis ; therefore , the use of nonsteroidal anti - inflammatory drugs ( NSAIDs ) has the potential of decreasing the risk of prostate cancer .
Linear regressions were performed on log - transformed PSA levels , accounting for the complex survey design , to evaluate the relations between PSA and the use of NSAIDs and acetaminophen after adjusting for the effects of age , race , educational level , smoking status , body mass index , coexisting inflammatory conditions , and heart disease .
PSA levels among NSAID users were 0.9 times the levels among nondrug takers ( P = .038 ) , whereas PSA levels among acetaminophen users were 0.76 times the levels in nondrug takers ( P = .14 ) .
acetaminophen consumption displayed a negative association with PSA levels , namely , individuals who reported using NSAIDs ( 19.8% ) or acetaminophen ( 1.3% ) regularly had lower PSA levels than individuals who did not take these drugs , although the impact of acetaminophen was not statistically significant .
acetaminophen consumption displayed a negative association with PSA levels , namely , individuals who reported using NSAIDs ( 19.8% ) or acetaminophen ( 1.3% ) regularly had lower PSA levels than individuals who did not take these drugs , although the impact of acetaminophen was not statistically significant .
acetaminophen consumption displayed a negative association with PSA levels , namely , individuals who reported using NSAIDs ( 19.8% ) or acetaminophen ( 1.3% ) regularly had lower PSA levels than individuals who did not take these drugs , although the impact of acetaminophen was not statistically significant .
To further characterize this association , the authors evaluated serum PSA levels with regard to NSAID and acetaminophen consumption in a large cross - sectional study of men in the US . METHODS .
Prostate - specific antigen levels in relation to consumption of nonsteroidal anti - inflammatory drugs and acetaminophen : results from the 2001 - 2002 National Health and Nutrition Examination Survey .
Individuals who stated they took both NSAIDs and acetaminophen ( 0.99% ) on a regular basis had higher PSA levels ( 1.8 times greater ) , although not statistically significantly so ( P = .24 ) , than individuals who stated they did not take either of these drugs regularly .
Inflammation has been implicated in prostate carcinogenesis ; therefore , the use of nonsteroidal anti - inflammatory drugs ( NSAIDs ) has the potential of decreasing the risk of prostate cancer .
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