Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

@article{Cohen1992ProstatespecificA,
  title={Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.},
  author={Perrin S. Cohen and Howard C.B. Graves and Donna M. Peehl and M. Kamarei and Linda C. Giudice and Ronald C. Rosenfeld},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1992},
  volume={75 4},
  pages={
          1046-53
        }
}
Insulin-like growth factor binding protein-3 (IGFBP-3), the major serum carrier protein for the IGFs, is absent from Western ligand blots of seminal plasma, but is detectable by RIA. IGFBP-3 protease activity has recently been described in pregnancy serum. We investigated the possibility that seminal plasma contains an IGFBP-3 protease, by incubating seminal plasma with 125I-labeled human IGFBP-3. Seminal plasma was found to have potent IGFBP-3 protease activity with a cleavage pattern… CONTINUE READING
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