Prostate-specific antigen: characterization of epitopes by synthetic peptide mapping and inhibition studies.

@article{Corey1997ProstatespecificAC,
  title={Prostate-specific antigen: characterization of epitopes by synthetic peptide mapping and inhibition studies.},
  author={Eva Corey and Sandra K. Wegner and Michael J Corey and Robert L. Vessella},
  journal={Clinical chemistry},
  year={1997},
  volume={43 4},
  pages={575-84}
}
To improve our understanding of the prostate-specific antigen (PSA) antigenic regions, we studied the association targets of one anti-PSA polyclonal antibody and 10 anti-PSA monoclonal antibodies (mAbs). We also examined the ability of the mAbs to inhibit PSA enzymatic activity and block the association of PSA with alpha 1-antichymotrypsin (ACT). Linear epitope mapping with a polyclonal antibody indicated the presence of six major antigenic regions in PSA. Examination of the panel of mAbs… CONTINUE READING