Prostate health index vs percent free prostate-specific antigen for prostate cancer detection in men with "gray" prostate-specific antigen levels at first biopsy: systematic review and meta-analysis.

@article{Bruzzese2014ProstateHI,
  title={Prostate health index vs percent free prostate-specific antigen for prostate cancer detection in men with "gray" prostate-specific antigen levels at first biopsy: systematic review and meta-analysis.},
  author={Dario Bruzzese and Claudia Mazzarella and Matteo Ferro and Sisto Perdon{\'a} and Paolo Chiodini and Giuseppe Perruolo and Daniela Terracciano},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2014},
  volume={164 6},
  pages={
          444-51
        }
}
The most promising approach to improve the specificity of prostate-specific antigen (PSA) test relies on the measurement of different molecular isoforms of PSA in serum. Currently, in men with a total PSA (tPSA) level between 2 and 10 ng/mL, measurement of %fPSA (free to total PSA ratio ×100) is used as reflex testing to better distinguish between malignant and benign prostate disease. Recently, Beckman Coulter developed the prostate health index (PHI) and several studies suggested that this… CONTINUE READING
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