Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer.

@article{Turner2007ProstatederivedEF,
  title={Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer.},
  author={David P. J. Turner and Omar Moussa and Moira Sauane and Paul B Fisher and Dennis K. Watson},
  journal={Cancer research},
  year={2007},
  volume={67 4},
  pages={1618-25}
}
Cell migration and invasion are critical events during the progression to metastasis. Without motile function, cancer cells are unable to leave the primary tumor site, invade through the basement membrane, and form secondary tumors. Expression of the epithelial-specific ETS factor prostate-derived ETS factor (PDEF) is reduced in human invasive breast tissue and lost in invasive breast cancer cell lines. Gain-of-function studies that examine different aspects of cell migration show that… CONTINUE READING
23 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…