Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis.

@article{Rubin2004ProstateCC,
  title={Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis.},
  author={Janet Rubin and Leland W. K. Chung and Xian Fan and Lijia Zhu and Tamara C. Murphy and Mark S. Nanes and Clifford J. Rosen},
  journal={The Prostate},
  year={2004},
  volume={58 1},
  pages={41-9}
}
BACKGROUND Prostate cancer (PC) has a propensity to metastasize to the skeleton, inducing an osteoblastic response in the host. Recent epidemiological studies have suggested that circulating IGF-I may be important for both the pathogenesis and dissemination of PC. We have postulated that tumor secreted IGF-I in conjunction with endogenous IGF-I contributes to the osteoblastic phenotype characteristic of metastatic PC. METHODS To test this thesis we studied the established LNCaP PC progression… CONTINUE READING
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