Prostate cancer tumor grade differentiation with dynamic contrast-enhanced MR imaging in the rat: comparison of macromolecular and small-molecular contrast media--preliminary experience.

@article{Gossmann1999ProstateCT,
  title={Prostate cancer tumor grade differentiation with dynamic contrast-enhanced MR imaging in the rat: comparison of macromolecular and small-molecular contrast media--preliminary experience.},
  author={Axel Gossmann and Yoshitaka Okuhata and David M. Shames and Thomas H Helbich and T. P. Pradeepa Roberts and M. Wendland and Sabine Huber and Robert C. Brasch},
  journal={Radiology},
  year={1999},
  volume={213 1},
  pages={265-72}
}
PURPOSE To differentiate prostate cancers of different histopathologic grades with dynamic gadolinium-enhanced magnetic resonance (MR) imaging. Results with a conventional small-molecular contrast medium (CM) were compared to those with a prototypic macromolecular CM. MATERIALS AND METHODS High- and low-grade tumors, sublines of the Dunning R3327 rat prostate cancer line, were subcutaneously implanted into the flanks of 12 male Copenhagen rats. Dynamic contrast material-enhanced MR imaging… CONTINUE READING

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