Prostate cancer stem cells: are they androgen-responsive?

  title={Prostate cancer stem cells: are they androgen-responsive?},
  author={Emma E Oldridge and Davide Pellacani and Anne T Collins and Norman J. Maitland},
  journal={Molecular and cellular endocrinology},
  volume={360 1-2},
The prostate gland is highly dependent on androgens for its development, growth and function. Consequently, the prostatic epithelium predominantly consists of androgen-dependent luminal cells, which express the androgen receptor at high levels. In contrast, androgens are not required for the survival of the androgen-responsive, but androgen-independent, basal compartment in which stem cells reside. Basal and luminal cells are linked in a hierarchical pathway, which most probably exists as a… CONTINUE READING
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