Prostate cancer progression, metastasis, and gene expression in transgenic mice.

@article{Perezstable1997ProstateCP,
  title={Prostate cancer progression, metastasis, and gene expression in transgenic mice.},
  author={C Perez-stable and Norman H. Altman and Pramod P. Mehta and LeonardJ. Deftos and Bernard A. Roos},
  journal={Cancer research},
  year={1997},
  volume={57 5},
  pages={
          900-6
        }
}
We previously reported that a transgenic mouse line containing the fetal globin promoter linked to the SV40 T antigen (T Ag) viral oncogene (Ggamma/T-15) resulted in prostate tumors. In this study, we further explored tumor origin, frequency, invasiveness, androgen sensitivity, and gene expression pattern. T Ag was detected in adult but not fetal and neonatal prostates, suggesting a role for androgens in tumor progression. However, castration shortly after prostate morphogenesis did not prevent… CONTINUE READING

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