Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.

@article{Stoyanova2013ProstateCO,
  title={Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.},
  author={Tanya I Stoyanova and Aaron R Cooper and Justin M. Drake and Xian Qi Liu and Andrew James Armstrong and Kenneth J. Pienta and Hong Zhang and Donald B Kohn and Jiaoti Huang and Owen N Witte and Andrew S. Goldstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 50},
  pages={20111-6}
}
The relationship between the cells that initiate cancer and the cancer stem-like cells that propagate tumors has been poorly defined. In a human prostate tissue transformation model, basal cells expressing the oncogenes Myc and myristoylated AKT can initiate heterogeneous tumors. Tumors contain features of acinar-type adenocarcinoma with elevated eIF4E-driven protein translation and squamous cell carcinoma marked by activated beta-catenin. Lentiviral integration site analysis revealed that… CONTINUE READING
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Australian Prostate Cancer Bioresource (2012) Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status. Stem Cells

  • RA Taylor
  • 2012
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