Prostate cancer mediates osteoclastogenesis through two different pathways.

  title={Prostate cancer mediates osteoclastogenesis through two different pathways.},
  author={Hitoshi Inoue and Kazuo Nishimura and Daizo Oka and Yasutomo Nakai and Masahiro Shiba and Takashi Tokizane and Yasuyuki Arai and Masashi Nakayama and Kiyonori Shimizu and Natsuki Takaha and Norio Nonomura and Akihiko Okuyama},
  journal={Cancer letters},
  volume={223 1},
The present study was undertaken to test the effects of prostate cancer cell lines (LNCaP, DU145, PC3, and MDA PCa 2b) on osteoclastogenesis. Crude conditioned medium (CM) from all four prostate cancer cell lines enhanced expression of the mRNA for receptor activator of NF-kappaB ligand (RANKL) in a mouse osteoblast cell line, MC3T3-E1; however, CM had no effect on expression of osteoprotegerin (OPG) mRNA. Coculture of MC3T3-E1 with prostate cancer cells yielded similar results. The number of… CONTINUE READING