Prostate cancer detection by GSTP1 methylation analysis of postbiopsy urine specimens.

  title={Prostate cancer detection by GSTP1 methylation analysis of postbiopsy urine specimens.},
  author={Mark L. Gonzalgo and Christian P Pavlovich and Shing M Lee and William Andrew Nelson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={9 7},
PURPOSE We assess the feasibility of a urinary test for prostate cancer detection in a high-risk patient cohort based on methylation-specific PCR analysis of the pi class glutathione S-transferase (GSTP1) gene promoter. EXPERIMENTAL DESIGN A total of 45 men underwent transrectal ultrasound-guided biopsy of the prostate for suspected malignancy. Clean-catch voided urine specimens were prospectively collected from each patient immediately after biopsy. Genomic DNA was isolated from urine… CONTINUE READING


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