Prostate cancer: another aspect of the insulin-resistance syndrome?

  title={Prostate cancer: another aspect of the insulin-resistance syndrome?},
  author={R. James Barnard and William J. Aronson and Christopher N. Tymchuk and Tung H. Ngo},
  journal={Obesity reviews : an official journal of the International Association for the Study of Obesity},
  volume={3 4},
Insulin resistance and compensatory hyperinsulinaemia are thought to be the underlying factors in the metabolic or insulin-resistance syndrome and can be controlled by diet and exercise. Hyperinsulinaemia has been shown to have a direct effect on the live, suppressing the production of sex hormone-binding globulin (SHBG) and insulin-like growth factor-binding proteins 1 and 2 (IGFBP-1, -2) while stimulating the production of insulin-like growth factor 1 (IGF-1). These factors have been proposed… CONTINUE READING


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