Prostate cancer: Antiandrogens reverse docetaxel resistance via ABCB1 inhibition

  title={Prostate cancer: Antiandrogens reverse docetaxel resistance via ABCB1 inhibition},
  author={Annette Fenner},
  journal={Nature Reviews Urology},
Antiandrogens such as bicalutamide and enzalutamide can resensitize docetaxelresistant prostate cancer cells to docetaxel treatment, by inhibiting efflux of the ATP-binding cassette (ABC) transporter ABCB1, according to a study published in Clinical Cancer Research. ABC transporters carry substances, including docetaxel, out of cells, reducing their intracellular concentration and, therefore, their efficacy. ABCB1 overexpression has been shown to confer resistance to chemotherapy and is… Expand
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