Prostate Cancer Cell Lines under Hypoxia Exhibit Greater Stem-Like Properties

@inproceedings{Ma2011ProstateCC,
  title={Prostate Cancer Cell Lines under Hypoxia Exhibit Greater Stem-Like Properties},
  author={Yuanyuan Ma and Dongming Liang and Jian Liu and Karol Axcrona and Gunnar Kvalheim and Trond Stokke and Jahn Martin Nesland and Zhenhe Suo},
  booktitle={PloS one},
  year={2011}
}
Hypoxia is an important environmental change in many cancers. Hypoxic niches can be occupied by cancer stem/progenitor-like cells that are associated with tumor progression and resistance to radiotherapy and chemotherapy. However, it has not yet been fully elucidated how hypoxia influences the stem-like properties of prostate cancer cells. In this report, we investigated the effects of hypoxia on human prostate cancer cell lines, PC-3 and DU145. In comparison to normoxia (20% O(2)), 7% O(2… CONTINUE READING
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