Prostasin is a glycosylphosphatidylinositol-anchored active serine protease.

  title={Prostasin is a glycosylphosphatidylinositol-anchored active serine protease.},
  author={L M Chen and Margaret L. Skinner and Steven W Kauffman and Julie Chao and Lee Chao and Catherine D Thaler and Karl X. Chai},
  journal={The Journal of biological chemistry},
  volume={276 24},
A recombinant human prostasin serine protease was expressed in several human cell lines. Subcellular fractionation showed that this serine protease is synthesized as a membrane-bound protein while a free-form prostasin is secreted into the culture medium. Prostasin was identified in nuclear and membrane fractions. Membrane-bound prostasin can be released by phosphatidylinositol-specific phospholipase C treatment, or labeled by [(3)H]ethanolamine, indicating a glycosylphosphatidylinositol… CONTINUE READING
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