Prostanoids stimulate K secretion and Cl secretion in guinea pig distal colon via distinct pathways.

@article{Halm2001ProstanoidsSK,
  title={Prostanoids stimulate K secretion and Cl secretion in guinea pig distal colon via distinct pathways.},
  author={Dan R. Halm and Susan Troutman Halm},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={281 4},
  pages={
          G984-96
        }
}
Short-circuit current (I(sc)) and transepithelial conductance (Gt) were measured in guinea pig distal colonic mucosa isolated from submucosa and underlying muscle layers. Indomethacin (2 microM) and NS-398 (2 microM) were added to suppress endogenous production of prostanoids. Serosal addition of PGE2 (10 nM) stimulated negative I(sc) consistent with K secretion, and concentrations >30 nM stimulated positive I(sc) consistent with Cl secretion. PGE2 also stimulated Gt at low and high… CONTINUE READING

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