Prostanoid Signaling Mediates Circulation Failure Caused by TCDD in Developing Zebrafish

Abstract

Using zebrafish embryos, we reported that 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD) evoked circulation failure through activation of the aryl hydrocarbon receptor type 2 (AHR2). However, the following molecular target after AHR2 activation is largely unclear. It has been reported that TCDD induces cyclooxygenase 2 (COX2), a rate-limiting enzyme for… (More)

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