Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection.

@article{PingeFilho1999ProstaglandinsMS,
  title={Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection.},
  author={Phileno Pinge-Filho and Carlos E. Tadokoro and Ises de Almeida Abrahamsohn},
  journal={Cellular immunology},
  year={1999},
  volume={193 1},
  pages={90-8}
}
Suppression of host lymphoproliferative responses to mitogens and Ag is characteristically seen during acute infection with the protozoan parasite Trypanosoma cruzi. We investigated the reciprocal regulation of prostaglandins (PG), TNF-alpha, and nitric oxide (NO) production and their effects on cytokine production and lymphoproliferative responses to parasite Ag and to Con A by spleen cells (SC) from T.-cruzi-infected mice. Large amounts of PGE2, TNF-alpha, and NO were produced during… CONTINUE READING
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