Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells.

@article{Weinreb1997ProstaglandinsIM,
  title={Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells.},
  author={Robert N. Weinreb and Kenji Kashiwagi and Fumiko Kashiwagi and Shigeo Tsukahara and James Lindsey},
  journal={Investigative ophthalmology & visual science},
  year={1997},
  volume={38 13},
  pages={2772-80}
}
PURPOSE To identify matrix metalloproteinases (MMPs) released by ciliary smooth muscle cells in vitro and to determine whether MMP release is altered by exposure to prostaglandins (PGs). METHODS Human ciliary smooth muscle cells were grown to confluence in monolayer cultures and treated with PGF2 alpha, 11-deoxy-PGE1, or PhXA85 (the nonesterified analogue of PhXA41) for 12 to 72 hours. The activity of MMP in the medium was assayed using gelatin and casein zymography. Identification of the… CONTINUE READING
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