Prostaglandins in bone: bad cop, good cop?

@article{Blackwell2010ProstaglandinsIB,
  title={Prostaglandins in bone: bad cop, good cop?},
  author={Katherine Anne Blackwell and Lawrence G. Raisz and Carol C. Pilbeam},
  journal={Trends in Endocrinology & Metabolism},
  year={2010},
  volume={21},
  pages={294-301}
}
Prostaglandins (PGs) are multifunctional regulators of bone metabolism that stimulate both bone resorption and formation. PGs have been implicated in bone resorption associated with inflammation and metastatic bone disease, and also in bone formation associated with fracture healing and heterotopic ossification. Recent studies have identified roles for inducible cyclooxygenase (COX)-2 and PGE(2) receptors in these processes. Although the effects of PGs have been most often associated with cAMP… CONTINUE READING
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