Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract.

  title={Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract.},
  author={Peter C. Konturek and Joanna Kania and Grzegorz Burnat and Eckhart Georg Hahn and Stanisław Jan Konturek},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  volume={56 Suppl 5},
This review was designed to show the role of expression of cyclooxygenase (COX)-1 and COX-2 in the cancerogenesis of esophagus, stomach and colon. Unlike COX-1, which is expressed in the normal esophago-gastro-colonic mucosa, COX-2 was found to be expressed mainly in the pre-cancer changes in the mucosa including Barrett's esophagus, Helicobacter pylori (H. pylori)-induced gastritis and inflammatory changes in colonic mucosa. In Barrett's esophagus, prostaglandins (PGs) derived from upregulated… CONTINUE READING
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