Prostaglandins as determinants of vascular reactivity.

  title={Prostaglandins as determinants of vascular reactivity.},
  author={J C Mcgiff and Kafait U. Malik and N. A. Terragno},
  journal={Federation proceedings},
  volume={35 12},
Prostaglandins are primarily local or tissue hormones that have their effects at, or near to, the site of synthesis. Some blood vessels synthesize prostaglandins intramurally, where their local release influences vascular tone and reactivity. Endogenous prostaglandins (primarily prostaglandin E2 (PGE2) participate in the regulation of vascular reactivity by opposing the vasoconstrictor and antinatriuretic actions of circulating pressor hormones; and by braking the release of norepinephrine from… CONTINUE READING


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