Prostaglandins and nonsteroidal anti-inflammatory drugs. Effects on renal hemodynamics.

@article{Dibona1986ProstaglandinsAN,
  title={Prostaglandins and nonsteroidal anti-inflammatory drugs. Effects on renal hemodynamics.},
  author={Gerald F Dibona},
  journal={The American journal of medicine},
  year={1986},
  volume={80 1A},
  pages={12-21}
}
Renal prostaglandins are important modulators of renal hemodynamic function. Their synthesis from arachidonic acid precursor is regulated by neurohumoral vasoactive substances as well as by intrarenal factors. Endogenous renal prostaglandins exert little influence on renal blood flow and glomerular filtration rate in the basal state. In contrast, inhibition of cyclooxygenase-dependent arachidonic acid metabolism with nonsteroidal anti-inflammatory drugs in states of decreased renal perfusion… CONTINUE READING