Prostaglandins and leukotrienes: advances in eicosanoid biology.

  title={Prostaglandins and leukotrienes: advances in eicosanoid biology.},
  author={Colin D. Funk},
  volume={294 5548},
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that are involved in numerous homeostatic biological functions and inflammation. They are generated by cyclooxygenase isozymes and 5-lipoxygenase, respectively, and their biosynthesis and actions are blocked by clinically relevant nonsteroidal anti-inflammatory drugs, the newer generation coxibs (selective inhibitors of cyclooxygenase-2), and leukotriene modifiers. The… CONTINUE READING
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