Prostaglandins, arachidonic acid, and inflammation.

@article{Kuehl1980ProstaglandinsAA,
  title={Prostaglandins, arachidonic acid, and inflammation.},
  author={Frederick A. Kuehl and Robert W. Egan},
  journal={Science},
  year={1980},
  volume={210 4473},
  pages={978-84}
}
The enzymatic oxidation of arachidonic acid has been shown to yield potent pathological agents by two major pathways. Those of the prostaglandin (PG) pathway, particularly PGE2, have been implicated as inflammatory mediators for many years. The discovery and biological activities of thromboxane A2 and prostacyclin as well as a destructive oxygen-centered radical as additional products of this biosynthetic pathway now require these to be considered as potential inflammatory mediators. Like PGE2… CONTINUE READING

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