Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?

  title={Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?},
  author={John L Wallace},
  journal={Physiological reviews},
  volume={88 4},
  • J. Wallace
  • Published 1 October 2008
  • Medicine
  • Physiological reviews
Except in rare cases, the stomach can withstand exposure to highly concentrated hydrochloric acid, refluxed bile salts, alcohol, and foodstuffs with a wide range of temperatures and osmolarity. This is attributed to a number of physiological responses by the mucosal lining to potentially harmful luminal agents, and to an ability to rapidly repair damage when it does occur. Since the discovery in 1971 that prostaglandin synthesis could be blocked by aspirin and other nonsteroidal anti… 

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