Prostaglandin-stimulated adenylyl cyclase activity via a pharmacologically defined EP2 receptor in human nonpigmented ciliary epithelial cells.

@article{Crider1998ProstaglandinstimulatedAC,
  title={Prostaglandin-stimulated adenylyl cyclase activity via a pharmacologically defined EP2 receptor in human nonpigmented ciliary epithelial cells.},
  author={Julie Y Crider and Brenda W. Griffin and Najam A Sharif},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  year={1998},
  volume={14 4},
  pages={293-304}
}
The goal of these studies was to compare the effects of several prostaglandin (PG) receptor agonists on adenylyl cyclase activity in transformed human nonpigmented ciliary epithelial (NPE) cells. In order to define the pharmacology of the PG receptors present on these cells, cyclic AMP production was measured by both manual and robotic radioimmunoassay (RIA) techniques. In NPE cells, the rank order of potency for the PGs tested in the current study (n = up to 46) was PGE2 (EC50 = 67 nM) > 13,14… CONTINUE READING