Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress

@article{Figarella2006ProstaglandininducedPC,
  title={Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress},
  author={Katherine Figarella and Nestor Luis Uzcategui and Adam J. Beck and Caroline Schoenfeld and Bruno Kilunga Kubata and Florian Lang and Michael Duszenko},
  journal={Cell Death and Differentiation},
  year={2006},
  volume={13},
  pages={1802-1814}
}
Recently, we reported the induction of a programmed cell death (PCD) in bloodstream forms of Trypanosoma brucei by prostaglandin D2 (PGD2). As this prostanoid is readily metabolized in the presence of albumin, we were prompted to investigate if PGD2 metabolites rather than PGD2 itself are responsible for the observed PCD. In fact, J series metabolites, especially PGJ2 and Δ12PGJ2, were able to induce PCD more efficiently than PGD2. However, the stable PGD2 analog 17phenyl-trinor-PGD2 led to the… CONTINUE READING