Prostaglandin-induced differentiation or dimethyl sulfoxide-induced differentiation: reduction of the neoplastic potential of a rat mammary tumor stem-cell line.

@article{Rudland1982ProstaglandininducedDO,
  title={Prostaglandin-induced differentiation or dimethyl sulfoxide-induced differentiation: reduction of the neoplastic potential of a rat mammary tumor stem-cell line.},
  author={Philip Spencer Rudland and A. B. Davies and Michael J. Warburton},
  journal={Journal of the National Cancer Institute},
  year={1982},
  volume={69 5},
  pages={1083-93}
}
Differentiation of the rat mammary stem cell line Rama 25 to alveolar-like cells was monitored both by the increased production of domes (hemispherical blisters) in the cell monolayer and by immunoreactive casein in the tissue culture medium. In addition to the synthetic inducer dimethyl sulfoxide (DMSO), prostaglandin (PG)E1, and to a lesser extent PGE2… CONTINUE READING