Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1).

@article{TaylorClark2008ProstaglandininducedAO,
  title={Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1).},
  author={Thomas E Taylor-Clark and B J Undem and Donald W Macglashan and Srinivas Ghatta and Michael Carr and Michael Allen McAlexander},
  journal={Molecular pharmacology},
  year={2008},
  volume={73 2},
  pages={274-81}
}
Inflammation contributes to pain hypersensitivity through multiple mechanisms. Among the most well characterized of these is the sensitization of primary nociceptive neurons by arachidonic acid metabolites such as prostaglandins through G protein-coupled receptors. However, in light of the recent discovery that the nociceptor-specific ion channel transient receptor potential A1 (TRPA1) can be activated by exogenous electrophilic irritants through direct covalent modification, we reasoned that… CONTINUE READING