Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins.

@article{Salomon1987ProstaglandinE2,
  title={Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins.},
  author={R. G. Salomon and M. Jirousek and S. Ghosh and R. Sharma},
  journal={Prostaglandins},
  year={1987},
  volume={34 5},
  pages={
          643-56
        }
}
Levuglandin E2 (LGE2), a gamma-ketoaldehyde produced by rearrangement of the prostaglandin endoperoxide PGH2 under the aqueous conditions of its biosynthesis, binds covalently with ram seminal vesicle microsomes. Totally synthetic 5,6-ditritio-LGE2 was prepared and used to determine that rapid covalent binding of LGE2 (initially 800 microM) occurs with 6.4 microM bovine serum albumin (greater than 10 equiv within 1 min) which approaches saturation (approximately 16 equiv) after 40 min at 37… Expand
Levuglandin E2 crosslinks proteins.
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Oxidized phospholipids, isolevuglandins, and atherosclerosis.
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