Prostaglandin biosynthesis and its compartmentation in vascular smooth muscle and endothelial cells.

  • W L Smith
  • Published 1986 in Annual review of physiology

Abstract

PGI2 is the major, if not the only, eicosanoid formed by smooth muscle and endothelial cells of large arteries and veins. PGI2 is not the major prostanoid synthesized by microvessels. Different stimuli elicit prostanoid production by smooth muscle and endothelial cells. PGI2 is formed at several subcellular sites within smooth muscle and perhaps endothelial… (More)

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