Prostaglandin biology in inflammatory bowel disease.

  title={Prostaglandin biology in inflammatory bowel disease.},
  author={John L Wallace},
  journal={Gastroenterology clinics of North America},
  volume={30 4},
  • John L Wallace
  • Published 2001 in Gastroenterology clinics of North America
Similar to in the upper gastrointestinal tract, prostaglandins represent one of the most important components of mucosal defense in the small intestine and colon. The effects of prostaglandins in this context are widespread, ranging from maintenance of blood flow to stimulation of mucus secretion to modulation of the mucosal immune system. There is little doubt that the ability of NSAIDs to cause injury throughout the gastrointestinal tract and to exacerbate IBD is due in large part to the… CONTINUE READING
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