• Biology, Medicine
  • Published in
    Investigative ophthalmology…
    1979

Prostaglandin and thromboxane synthesis by microsomes of rabbit ocular tissues.

@article{Kass1979ProstaglandinAT,
  title={Prostaglandin and thromboxane synthesis by microsomes of rabbit ocular tissues.},
  author={M. Andy Kass and N J Holmberg},
  journal={Investigative ophthalmology & visual science},
  year={1979},
  volume={18 2},
  pages={
          166-71
        }
}
Microsomes of albino rabbit ocular tissues were incubated with (1-14C)-arachidonic acid for 15 min at 37 degrees C. Thin-layer chromatography revealed that ciliary body-iris microsomes were capable of synthesizing prostaglandin F2alpha (PGF2alpha), PGE2, PGD2, thromboxane B2(TXB2), and 6-keto-PGF1alpha. Indomethacin 14 micrometer in the incubation medium essentially abolished all prostaglandin synthesis detectable by this method. Imidazole 10 mM in the incubation medium inhibited only TXB2… CONTINUE READING

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